I had a similar problem with a an engine like yours and decided, in for a penny in for a pound and did a complete engine rebuild. I am sure that if I had just addressed the single bad piston/cylinder, I would have had a decent running engine, but I wanted to have something which I could rely on as a daily driver, and have never looked back. These engines are impressive in these old trucks when all-new inside.
Carl


1952 5-window - return to "as built" condition | 1950 3100 with a 235 and a T-5 transmission