Having done two off frame restorations (my '50 COE and '37) I would recommend removing the cab. You will discover some things that you will want to fix early enough in the process to make it easier. A totally stripped cab only weighs about 370 lbs, so you and 3 of your friends can easily lift it off; or use straps and an engine cherry picker. Get a decent wooden pallet and buy some cheap swivel caster wheels at a big box store and make yourself a cab dolly. The cab can also be rolled on its back with some padding to work on the underside. Follow Kevin's advice and you will be fine.
Kent


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1950 Chevy COE Model 5700 ~ "Barney" ~ And more pix