You cooling system, if in good shape will be enough. You will have to modify the right motor mount and the pulley alignment maybe a little different. You exhaust pipe will need to be changed from the muffler to the manifold, 292's are about 2" taller so your pipe will be short, plus 292's use bigger diameter pipe. The fuel line will need to be changed a little, 292 fuel pumps are in the center of the right side where as 250's are towards the front of the engine. Joe