I've been meaning to look into that as well, could be the simplest option.
However others have looked into this and never report back with a completed solution either simple or difficult, so far no results that I know of for single wheel 8 lug disc on original axle or hubs. This is why I didn't investigate this rout first, I trusted that others have, but I'm beginning to think I should at least give it a few hours of searching and figuring to decide for myself.
It'll take a fabricated caliper bracket for sure.

I'd also like to investigate original spindles and axle with different hubs.
Until I get a chance to pull my original 1 ton axle apart does anyone have any bearing numbers or diameters for the original stuff?

Grigg



1951 GMC 250 in the Project Journals
1948 Chevrolet 6400 - Detroit Diesel 4-53T - Roadranger 10 speed overdrive - 4 wheel disc brakes
1952 Chevrolet 3800 pickup
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"First, get a clear notion of what you desire to accomplish, and then in all probability you will succeed in doing it..." -Henry Maudslay-