I might as well toss in my 2 cents in on this. Anyone who knows me knows that I am a big fan of the 250. I used to drive a ton and a half dump with a 292. It was rode hard and put up wet day in and day out. The only problem that I remember was a cracked exhaust manifold. It got 16 mpg loaded or empty, fast or slow, period. One of my 250s in a C-10 with a shell on the bed got 17-18 mpg and that went down over about 65 mph. Both engines had more than enough power to do the job, and pushed hard the C-10 would bark a puppy in second. What more could anyone want? The hop-up stuff doesn't give enough go for the $$$$ to suit me generally, and the shiny stuff will always be there.
Best wishes,
Les