Ive had a few of those s-10 engines and I wouldnt recomend one. Mine did fine for the use I put it to, but I was constantly fixing it. They shake and vibrate very detrimentally for an engine. I had more pieces shake themselves off those engines then in all the combined vehicles Ive driven.
The oil filter extension that wraps around the motor mount is bound to leak. I fixed mine numerous times and tried lots of different ways and the best I could do was slow the leak down to a minor leak. They have a nightmare of vaccum lines and as mentioned the carburetors have their own complicated set of problems.
I would say your better off using an inline 6 or stepping up to the 4.3 which would be the easiest bolt in replacement.
Jeff