I have a Dana 80 in mine with the same bolt pattern.I use P-30 motorhome 19.5 modern radial tires.Tires are a little smaller in diameter then the originals but they can handle 75MPH and can be replaced anywhere in the country.

Big block with a TH400 and a 33% overdrive behind that.

You could consider a 700R4 overdrive transmission to bring the RPMs down.