I may be wrong here, but rotation is not the issue in this swap. The issue is the location of the shifter on the tail housing. The S10 is located farther forward than the Camaro, placing the shifter in a more original position in an AD truck. Just my two cents.
You would be surprised how many people have said to me that they "didn't want a Camaro T5 because it was rotated" which of course is a misunderstanding on their part. You are correct that rotation is not the issue. The biggest issues are
1. Finding an S10 tail housing with a cable style speedo drive.
2. Making the S10 tail housing swap. (Actually pretty easy).
3. Using an adapter plate ($160). This is not necessary if you use a V8 Camaro/Firebird T5 or a T5 from an Astro/Safari van.