Might as well toss in my $.03! "If you can think it...it CAN be done."
However, as the owner/builder of several rather radical BB trucks I think a potential builder should have a clear picture of what you will ultimately wind-up with. A lot of time and money in a vehicle that has some really limited use potential.
If you have an unlimited budget (yeah right!), the necessary equipment to fabricate all the hardware, the time to fit and refit and get it right, you may wind up with a "running hunk of plunder" that turns heads, but is it going to be something you actually want to drive? How can I ask this...because I've gone that route a number of times, and have figured out when it's all said and done, that BIG POWER isn't all it's cracked up to be. Unless you're willing to go all the way with the major systems, you're going to have a rocket that sucks gas, handles like a UPS truck, and spends more time in the shop than on the road.
I guess if that's what flips your skirt, it may be worth it but, if you're looking for something dependable to cruise and enjoy, you might be better served to choose a better matched setup. Case in point....I drive my little tweaked 6 banger Chevrolet everyday while my 1964 BBF "Lightening" is relegated to an occassional show or two. It's not a "brand thing"...just being practical! With fuel headed for $5.00/gallon all those horses under the hood may just be a drain on the ole wallet. Oh that's right, money is no object!!!!
Sure, you can build your machine any way you want, but if choose to go with big horsepower, you'd better take a much closer look at the "Big picture." The bucks/time/equipment necessary to make some of these "exotic" transplants might be better left to Jay Leno.
Maybe I'm just getting older....or maybe smarter!!!
Dave