For the purist, inline 6's are still cheap and available.
Last year I aquired a 1/2 ton Chevy with a 4.3 V6. I have become a big fan of them after driving it. I think it would actually be a good performer in the AD trucks with a overdrive transmission and the correct rear end, unless you plan on towing or hauling heavy loads. For cruising and loads 400 to 600 lbs I think it would do a great job. With 160 hp and 230 torque from a stock engine, with all the aftermarket parts made for them I think it would make a nice daily driver (even stock).
When Chevrolet decided to add a turbocharged 4.3L in the Syclone pickup & Typhoon SUV, the vortec headed V6 with multi point fuel injection & some serious boost, both torque & HP were increased to 280 horse power & 360 ft.lbs of torque.
The early throttle body fuel injection I believe only requires 12-13 lbs pressure.