Given how much easier it is to make an inline work in one of these trucks I'd sure rather swap in an inline than a small v-motor.
The 4.3 is going to be all the work and disadvantages of a V-8 but few of the advantages. A 292 inline is going to have better torque, similar horsepower, and be a much easier swap.
But then I'm putting a 500 Cadillac in mine so what could I possibly know...