How about some pictures of what is going on. Its hard to imagine that you could have everything centered up and not have them lined up.
As far as I know a t221 is a center output not offset. If your tc output is centered and your rear end yoke is centered, they should line up.
You cannot run a crooked driveshaft unless you want to tear up u joints and take the chance of putting the shaft in a bind. How far off are they? Jeepers transpanting V8s regularly offset their engines/trans/tc setup one inch.
Chris