Yes there are pros and cons to v8 over inline 6
The main con of the v8 is the exhaust and steering
And it burns more gas.
Ferris Bueller is running a pretty stout 383, with tbi and getting 18.5 mpg. He's also running a 5 speed tremec.
I'm not familiar with inline 6 bangers so can't compare fuel milage to that
The 4l60e will require a pcm.
You did not mention budget. A long block 350, set of vortec heads, vortec specific intake, center bolt valve covers, and a tbi will set ya back about $5k.
Just a thought
