I worked on 292 engines in step vans for many years. There is no reason you can't get 12-15 mpg in a pickup that is tuned right & geared right. They are a rugged engine. We used to drive them with the throttle to the floor mile after mile & never blew one. They can be noisy though. The heavy duty versions have forged pistons that rattle when they get worn some.
I still would prefer the 350 v-8 though.
George