Why would you go with a FiTech system, when the OE Fuel injection is already tuned/made for the motor?
Anyhow, if one were to install some sidedrafts or ITB's that would cool. The achilles heel would be the ignition. There's a ton of belt drive ignitions out there for anything V8, just haven't seen anything for a 6. I just saw one for a newer 5.0 Coyote, which got my wheels spinning. If one were to get rid of the 4200 AC pump, build a bracket and mount a CCW ignition, like a Willy's 226, with the cap facing the firewall. Well, a belt drive ignition may be possible for the 4200... Drive cogs and belts are fairly cheap, it's the machine work that'll be the big issue.