Not without some modification. The 54-up 235 and 261 engines have larger cam bearing journals than the 216 and pre-54 235 engines. On a whim earlier this year I did some experimenting on a 235 cam with one worn out lobe- - - - -chucked it up in a lathe and used a carbide cutting bit and a tool post grinder to resize the bearing journals to 216 dimensions! It slipped right into a spray-oiler 235 block that was also used for experimentation on the one-piece rear oil seal project. I see no reason that the "Corvette" 261 cam can't be fitted to a 216 engine with a little bit of machining.
Jerry

"It is better to be silent and be thought a fool than to speak and eliminate all doubt!" - Abraham Lincoln
Cringe and wail in fear, Eloi- - - - -we Morlocks are on the hunt!
There is nothing noble in being superior to your fellow man; true nobility is being superior to your former self. - Ernest Hemingway
Love your enemies and drive 'em nuts!