As you can see with your combination, unless someone has actually done it with those exact components, we can only give general swap advice. The answer is ALWAYS in the mock up. Then you will have specific questions we can answer.
"Going to work well together" is subjective. The motor, tranny and differential ratio lean towards highway cruiser more than breaking tires loose. The "direction" you go is your decision.
With all you are doing, (redesign of the truck mechanicals, suspension and drivetrain), you will have problems to work out, fabrication and some money to spend. As said, it can all be done. Has all been done. If these are the components you want to use, put them together and mock it all up. Clearances to: radiator X,Y and Z position, cross members, firewall, steering box, exhaust, body clearances..... an eye on pinion angle, motor and trans mounts, shifter, drive shaft yokes. Then lock it all in and wire it, plumb it, hose it and tail pipe it.
