There's an old guy in town here that drives am early regular cab long box GMC S15 4X4 with a five speed tranny and a 4.3 V6. I've always thought that if that truck came up for sale I would buy it and put my '53 GMC on it. If I got tired of the V6 I could stick a V8 in there. With an S10 or S15 long box you would have the correct wheel base, IFS, 4 wheel drive, power steering, disc brakes, etc. etc., and the wheels would sit inside the fenders for a stock look.
Yep. The S-10 swaps drive and handle awesome as well. I know, I have an original S-10 with a 350 in it, and my '46 is on an S-10 frame.