An S-10 frame is a great choice. They're fairly easy to do on the AD trucks, and it makes the truck handle like a sports car. If you need chassis parts, you go to a parts store and buy the part for an S-10. It's a no-brainer, in my opinion.
My dad has a '52 on an S-10 with a 454, and I'm currently building a '46 GMC on an S-10 with a 455 Buick.