I have a frame mounted booster in my 59 gmc. The only clearance issue was with the ebrake cable. There is a pully that needs to be relocated about 3 inches further back on the frame. My truck has a very large 5 speed (NV4500) and Pontiac V8. I have to point out the factory positioning for the chevy and gmc V8s were different, with the gmc v8 being about 4 inches further forward. I can not see this being any type of factor.