The frame is plenty strong, and the small block V-8 actually weighs less than the 6-cylinder by a little bit. You'll encounter some interference problems between the steering column and the driver's side exhaust manifold. If the truck has not been converted to 12 volts, that will be necessary, as it's difficult, if not impossible to swap the V-8 starter and ignition system over to 6 volts. There should be some good info on both exhaust systems and 12 volt conversion in the tech tips section.
Jerry