I don't recall the exact numbers, but the last 250 I built got 307 pistons, AND a .050" head mill, and it still runs on regular gas, with a stock cam, and doesn't detonate. I figure that's about the ragged edge of too much, though!
Jerry
Edit: The 250 rod length is WAY different than a V-8, so you'll need to use the 6-cylinder rods, not the smallblock V-8's.
Jerry