I'm planning to run a Quadrajet on my current project. I have several of the later ones, just before they started putting wires to them, and were designed for the motors I plan to run.
I've gone ahead and bought both the book Rochester Carburetors by Doug Roe and How to Rebuild and Modify Rochester Quadrajet Carburetors by Cliff Ruggles. I know a couple of books won't assure me no problems with these carbs, but my overview of the books suggests to me that these carbs are extremely adjustable and that many of the problems people complain about come from a short list of easily corrected wear areas.
Unfortunately my life has forced my projects to move real slow and I now doubt I'll have a rebuilt Q-Jet on a runner in 2010 so it may be a while before I can confirm my assumptions or be forced to admit defeat.