Robert,
I'd go with what you're familiar with. Most carb's will work 'out of the box' but will never run 'perfect'. Personally, i thnk once you've tuned and jetted a carb for your motor, you'll never bolt one on out the box ever again. Big difference. You can either set it up yourself, or have it sent to somebody to be tuned probably by a speed shop. Holley has a nice DVD that walks you through setup when you purchase a new carb I believe. Having said that, I have used both and like the edelbrock. I got 4 years out of mine before I had to rebuild it, they're basically a carter carb. The holley's are a little more tricky, but still not as finicky as a weber, so it's all relative. The holley's have a tendency to leak because their bowls are side mounted and fuel always sit in the the gasket. If your truck sits a lot, they will ivariably leak. These new ethanol blended fuels are murder on plastics and gaskets. My edelbrock had issues with jet's plugging and gaskets leaking too, just not fuel leaking, so they all have their own demons. Pick the carb that you know unless you want to learn a new and mess with a new one, which can be fun too! Once you tear down a holley, it's not that scary.
Good luck with the Cancer, we'll have you in our prayers.
Last edited by pplummer; 01/10/2010 5:00 PM.