Personally, I prefer the 6V53 over the 453 but they are a little wider and heavier.
And louder
The truck I had with a 6V53 and twin turbos was a lot of fun to drive, and very useful, but sure was loud, and fuel economy was nothing special. I think I'll like my 4-53T, but on occasion I'll miss the HP that the 6V53T had.