I just did an autopsy on a small block 350 that made about 550 HP on my dyno. It burned two pistons recently. The owner of the engine, who is one of my former students, told me he found the spark plugs on the #3 and #5 cylinders with the electrodes burned away, and discovered a couple of loose intake manifold bolts. He retorqued the manifold, replaced both plugs, and got about another 1,000 miles out of the engine before the tops of the pistons went away. It's no fun at all to get a vacuum leak at full throttle. The damage is extensive, and immediate!
Jerry