There is a local guy I see from time to time that has a '54 GMC 1/2-ton long box (only on a GMC) with axles under it from that era Chevy 4x4 pickup.
It is lifted pretty tall, and looks sharp for that kind of rig. The wheels and tires don't stick out any more than what you often see on an agressive lifted 4x4. If that's what you want it should be great.
I think I'd go S10 if I wanted 4-wheel drive...
Check this link to see that approach done.
http://www.commerce.usask.ca/staff/hipkin/burb/