I've installed a 350 into my '48 1 1/2 ton. There wasn't anything too hard to make or modify, but there is alot of fab work even using upgrade kits. I didn't use any kits so the engine cross member was the hardest thing to fab. A lot of little things to do that takes time. I used exhaust manifolds, so I had to "clearance" the right one. Had to make my own throttle cable set-up and make the brake pedal clear the left exhaust manifold. Also had to find the correct bell housing for the small block and it still required some modification. My suggestion would be to pull the front clip and make plenty of room to work and attack each problem as it comes.
Scott