If the cab mounts are in good shape, you shouldn't have any problems with realignment. With the cab off, you won't be impaling your shins on the running board brackets.
The cab is easily picked off by 4 guys, or using an engine hoist with a plank on the boom extending thru the door openings.
My cab had to come off because I needed to rebuild the floor. After taking it off the rotisserie, I put it on a pallet with casters bolted on it. I need to add some blocks to raise it up a bit, though, so I don't have to lay on the ground to paint the bottom edges.
