I have machined a crankshaft for an AMC V8 while it was installed in the engine, but we stood the engine up on the harmonic balancer, leveled it in all directions, and used a precision boring head in a radial drill press to machine an accurate hole. That one was set up for a different torque converter since the year of the engine didn't match the vehicle it was being mated with. AMC had swapped from a Borg-Warner transmission to a Torqueflite, and the TF had a different converter snout dimension.
Jerry