Thank you all for the replies. I really appreciate the input (no pun intended)! I'm venturing into uncharted territories with my project, but really enjoying learning new stuff.
It had not ocurred to me that the crankshaft (in an older motor, like a 235) would be drilled for a pilot bushing regardless of which transmission it was mated to.
In my case, I have a later model 250 (non running) mated to a Turbo 350 in my '51 Chevy project. I acquired a 4-speed SM 420 a while ago to replace the auto. I haven't pulled the motor and trans out of the truck yet so I haven't seen the rear end of the crank. My dad commented that I may have to replace the crankshaft. I was planning to rebuild the 250 but just discovered it has freeze damage so now I'm looking at a replacement. I wanted to be sure, when I go look at another motor, that I wasn't getting one that needed a new crankshaft. Long story short, as long as the crank is drilled for a pilot bushing I'm ok.
Many thanks again, and Merry Christmas!
Brian