Gearing-gearing;Don't trade away that set of 16's!!Swapping from 235/75R-15's to 235/85R-16's will improve your gearing noticeably.
Driving with my tailgate down CONSISTENTLY gives me 2 to 3 miles per gallon improvement.
A small 4 barrel,properly jetted,is worth some more savings.
Make sure you don't have a wheel brake or your e. brake dragging.
Keep your trucks alignment correct.

Keep your u-joints properly lubed.
A cruise control will help your mileage on the highway.
Synthetic lube in the transmission and rear end is a good thing.
I guess,if you wanted to really get into this,a lighter flywheel and smaller diameter clutch would take less horsepower to spin,but that's getting deep into the nit-picky details.
Speed


1954 GMC 350
1957 GMC 1/2 ton
1962 Chevy C-30
1952 Chevy 6400 dump bed project truck
'98 Harley FLSTC
'66 Pontiac Catalina
'76 Chevy 1 ton Duallie
'84 Bronco II
'78 Dodge W-200
'81 Toyota 4X4 truck