You'll need to do some serious beefing-up of the front springs to carry the weight, and it's highly unlikely the gearing of the transmission and rear end will be compatible with the relatively narrow power band of a 2-stroke Detroit. You need another gear for about every 400 RPM the engine accelerates, as the normal power band is only from 1750-2150. A 4X3 setup with a Brownie between the transmission and the rear end would probably be necessary, plus a little practice stirring two shift sticks. An oldtime Detroit driver I knew used to say "I don't really drive this thing- - - -I row it with the shift levers!"
LOL!
Jerry

"It is better to be silent and be thought a fool than to speak and eliminate all doubt!" - Abraham Lincoln
Cringe and wail in fear, Eloi- - - - -we Morlocks are on the hunt!
There is nothing noble in being superior to your fellow man; true nobility is being superior to your former self. - Ernest Hemingway
Love your enemies and drive 'em nuts!