Yup, that's for sure. In fact, I think Mr. Clifford, from Clifford Performance, used to race stovebolts against the early V8's with good success.
No doubt you can make a Stovebolt perform, but the Hot Rod article seemed to indicate that the horsepower was still limited to the 300 horse range. It's the super flat, strong torque curve that makes these engines great. So I have no doubt that they'd pull the wheels up, built right.
But the cost might be pretty high, to build one of these I-6's, especially if you get the EFI set up and the modern aluminum head.
If I had two of these trucks, I'd definitely build one of them with an inline 6 built up, and the other one with a V8. There are times when I'd like both set ups for their own merits.