Absolutely. You can theoretically build almost any popular engine, and it is not restricted to American engines. There are some European and Japanese engines too. Or, if you know the bore and stroke, you can set up an engine that is not loaded into the program.
Basically, Dyno 2000 is a desktop dyno and is about the most reasonably priced desktop dyno you can find. There are better ones that are a lot more accurate, you do get what you pay for. But for the money, Dyno 2000 is decent.
It has some limitations, they never could get their turbo program to work right, although their supercharger program works fine. (???). Also, some generalizations are made that are not correct, such as the bigger is better carb myth, and no difference between a 60's dual plane and a modern 2004 dual plane.
But for comparing cams and getting a general idea of what your optimum sealevel power/torque curves look like, it's pretty good.
Definitely worth $60 bucks or so.