The bigger carburetors do not get the air volume needed to work correctly, I won't say it won't run, it just won't run like you want it to. I have run different manifolds with and without heat, and here in Kansas City, you need heat under the carburetors, the more the better. I always had iron or steel manifolds so they retained some heat, the aluminum is going to give it up much faster, so apply as much heat to the carbs and manifold as you can if you live anywhere it humid or gets cool. It really helps on restarts after 10 or 15 minute shut downs.
I guess I didn't know the 216's used Rochester carburetors, I thought they all were Carter W-1's.
