I'm with Marko. Media blasting will do the best job. I would follow it up with Ospho, and wipe it down with acetone after 24 hours and prime it, force a bead of sealer into the seam wiping away the excess, then paint it.
A wire wheel will likely just beat rust particles into the seam which will come back to haunt you.
Carl

Last edited by 52Carl; 08/10/2016 3:08 AM.
1952 5-window - return to "as built" condition | 1950 3100 with a 235 and a T-5 transmission