A V8 swap is certainly do-able, but there are some challenges. One is the steering and exhaust clearance, another is motor mounts, a third is getting the fan up to the radiator or shrouding it, etc.
All these problems are solvable. All ya need is $.
Given the relative ease of rebuilding, and mildly hopping up, that 250 6, I'd consider that if it was me...
George