No need to wonder, I do have a 350 Holley 2300 series carb on a 261 with a modified stock manifold.Forget the adapters,they mess up the mixture and limit the flow.
2300 Holley I enlarged the carb opening to an oval shape in a stock intake using common tools,had to weld up a few holes as the porting operation get into the exhaust heat riser part of the intake,I wanted to retain the heat riser for street use.Then made a carb mounting flange from phenolic cause I can work it wood working tools and it's a good heat insulator .Drilled and tapped a few holes to bolt the plate on,heli coiled the carb mounting bolt holes,made a cross over piece for the linkage. On my set up,the carb sits fuel bowl foward.
The Holley on modified intake has great throttle response,more power and yes ,better fuel mileage than the stock carb or those ugly over rated Holley Weber 2 bbl carbs.