If your 216 uses 14mm threaded spark plugs, they will work, but may be one range hot. The '50 VIKs at the GM Heritage Center Archive site list the 46-5 as original for cars with the 216, and the 44-5 as original for truck 216s. For a lightly driven truck, the hotter plug may be a good choice.
Since the "dash 5" plugs are in demand for "correct" restorations, and not terribly common any longer, I have a couple sets on the shelf, and run modern AC plugs in my Chevys, FWIW.
FYI, you may find the VIKs
HERE, if you've not accessed them in the past. Lots of great info. Select the link for car or truck, scroll down the your model year, and the .pdf of the original Chevy documentation will open.
Doug