One of the options I'm considering for my truck, but I'm not sure I am going to do it. I'm currently leaning away from doing it.
Relocate the fuel tank under the bed. Use the existing tank behind the seat as a speaker box. It could be opened, sound insulated, and modified quite a bit without interfering with anything else in the truck. It would be easy to put back to stock if you want to go back by just replacing the tank.
Just a thought.