4x4 s 10 is a different width and from what I have read about the s10 frame swap the 4x4 rear end fits for width. You may want to do a search to find out.
It depends on what your final plan is. I'm using the 2WD S-10 rear end in my 46 GMC so that I can run bigger wheels and tires in the back and fill up the fender wells. Mine is going to be fairly low, as well though.
