Oldkoot, should work. Iron duke from what I read run 84 horsepower for carb models, 92 horsepower and up for fuel injected. Depends on what year iron duke you get. fuel wise I would say it was a power to weight thing. Consider the truck you buy to set on the s 10 chasis. Most s 10 frame swaps I see are later 40's to early 50's chevy advanced design. The frame engine, trans and front and rear axles with springs,wheels and tires on these trucks compared to s10 running chassis. The s10 I should think is 600 to 800 pounds lighter. I think what you'll have is an old looking truck that runs and drives like an s10 with a iron duke in it. I would get the fuel injected model more power and better fuel economy.
jbennett
40 burb