Well, I'm still running a stock setup on mine until I get it rebuilt (it smokes a little), but I have been drooling over Holley's new closed-loop throttle body fuel injection (Commander TBI). Unlike their old system, this has a real computer that you can program the fuel maps with a laptop, and it runs a manifold pressure sensor, a ignition sensor, and a O2 and knock sensor. It can be tuned really well and uses GM parts for the fuel injectors. It can be fit to any engine from a 4 cylinder up to a big block, just by selecting the injector/tbi size, and it costs about $1500. It can even be set up to use a turbo or supercharger. The only thing is that no one has developed any 235 or 261 fuel maps for it so you will need to take a lot of time to get it well tuned.
I was going to do a sixpack kind of system with Holley 94's, but I think I might go directly to fuel injection. It's going to be a while, though, since I need to get the truck painted and the 261 rebuild. I have a 235 in the garage as a spare though.
