I have 5200 miles on my 49 Suburban including a couple of 500 mile plus trips. 283/TH350/2:73. I have no problem keeping up with traffic even on the Interstate. Anything over 60 requires constant attention on what is going on in front of you. If you are going to go much over 55 you need good brakes and positive steering. I have found that the Suburbans/Panels with their higher center of gravity do not handle well in a stiff crosswind at speeds much over 55. Pickups might be OK. Like oldbluetruck says interval is the key. I also think that the aerodynamics of these old trucks do not lend themselves to the higher speeds. They were just not built to go fast. They were meant to do chores around the farm. However this is only my opinion.
Weeds