I have had OD and 3.38 gears in my 59 gmc. It wasn't an ideal setup, so when the perches were ripped off the 3.38 rear, I went to a 3.70 ratio in an after market rear.

Ghost rider, double check that rear ratio. I suspect it is a 4.11, which will work very well with an OD transmission

4.11 gears with an OD transmission, will feel like 3.00 gears. If you have the 4.56, they will feel like 3.32 gears in OD. You are lucky to have the open rear the 3/4 tons offered, makes things a bit easier.
John