No. Maybe if I was going to race the truck or something, I might box the frame, but I'm just going to use it as a daily driver. I will run a strait six, manual trans, strait axle and no darn radio(unless my wife makes me). There is nothing wrong with the frame the truck came with. Others may disagree, others on this site have done the S10 swap and are happy with it. I enjoy driving my truck too much to tear it down and not get to drive it for months.
It's your truck, do what you want, make it your's.
Also I have an aversion to doing the 'knee jerk reaction' to these trucks. That includes S10 swaps, V8s, mustang II front ends, bucket seats, and automatic transmissions.
Please see my earlier disclaimer