It comes down to a balance of purpose against resources. If you want something different a small block isn't likely going to offer that. If you want tons of power you need big cubes and there are no cheap ways to do that unless based on cheap cubes.
Once you have a clear idea your purpose and the limitations on your resources the other decisions should not be too hard to make.
Last edited by OldSub; 04/21/2010 12:10 AM. Reason: Spelling. Again.