My frame is coated in 60 year old rust. However in the past on a few projects I used POR15, then sprayed 2-part PPG epoxy primer over it within the proper window and top coated with a custom mixed PPG color.
I have also helped a friend with his rock-crawling jeep. had the frame powder coated, then rhino-lined. The body was painted in rattle can primer as it was a trail vehicle.
If your doing a driver, I wouldnt make it too pretty, as you will go insane with touchups and waxing it. If its a show piece, then go nuts.