I run 3 Rochester's on my 250, they are off a Corvair and are quite small, somewhere around 70 cfm each. It runs OK but nothing to brag about. Fuel mileage might be just a bit better at lower speeds, but worse out on the road. They are a pain to get jetted right.
Mine changes with the weather more then a single carb does, now that its cooler, I am going to have to pull the tops off and re-jet or lower the floats. Either way I go, its an hour job! Even day to day it runs different.
Joe